This is a visualization of the pseudorotation concept in five-membered rings.
You can adjust pseudorotation angle P and the amplitude ν_max by moving the sliders or
positioning the cross-hair on the right-hand side graph to see the changes in the
conformation. One atom is colored to serve as a reference atom. It can be thought of as the furan
oxygen. You can find more information about pseudorotation and conformations of nucleosides and
nucleotides in the following papers:
- J.E. Kilpatrick, K.S. Pitzer, and R. Spitzer, J. Amer. Chem. Soc., 69, 2483 (1947)
- K.S. Pitzer and W.F. Donath, J. Amer. Chem. Soc., 81, 3213 (1959)
- C. Altona and M. Sundaralingam, J. Amer. Chem. Soc., 94, 8205, (1972)
Please note that for large amplitudes ν_max the approximations made in constructing this model
might no longer be valid and the resulting 3D representation here should be thought of as a
general visual aid tool not a specific molecular structure. This is also the reason why the
interactive tools limit selection of ν_max values to 40 degrees or less. The data points shown
in red are the pseudorotational parameters for β-nucleosides in the
Cambridge Structural Database,
as evaluated using our PROSIT tool in:
- Guangyu Sun, Johannes H. Voigt, Igor V. Filippov, Victor E. Marquez, Marc C. Nicklaus,
"PROSIT: Pseudo-Rotational Online Service and Interactive Tool, Applied to a Conformational Survey
of Nucleosides and Nucleotides", J. Chem. Inf. Comput. Sci. (in press).
Dr. Igor V. Filippov , SAIC-Frederick, 2004
Last Change: 2004-06-14 M. C. Nicklaus
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