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Technologies Available for Licensing

Technologies Available for Licensing

For Licensing Opportunities, please contact the ORTA at USAMRMCORTA@amedd.army.mil


METHOD OF DESIGNING SYNTHETIC NUCLEIC ACID SEQUENCES FOR OPTIMAL PROTEIN EXPRESSION IN A HOST CELL

The present invention provides a method for modifying a wild type nucleic acid sequence encoding a polypeptide to enhance expression and accumulation of the polypeptide in the host cell by harmonizing synonymous codon usage frequency between the foreign DNA and the host cell DNA. This can be done by substituting codons in the foreign coding sequence with codons of similar usage frequency from the host DNA/RNA which code for the same amino acid. The present invention also provides novel synthetic nucleic acid sequences prepared by the method of the invention.

Number:2004-0005600

Application:10/404,668

Date:2004-01-08

Type: Pending

Category: Method

More Detail:Visit USPTO.GOVExternal link

For Licensing Opportunities, please contact the ORTA at USAMRMCORTA@amedd.army.mil
 
 

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