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EXTRANEOUS DNA SEQUENCE THAT FACILITATES HANTAVIRUS GENE EXPRESSION
In this application is described a protective DNA vaccines against infection with HFRS- and HPS-associated hantaviruses. The vaccines were constructed by subcloning cDNA representing the medium (M) (encoding the G1 and G2 glycoproteins) into the DNA expression vector pWRG7077. Animals vaccinated with the M construct developed a neutralizing antibody response. Passive transfer experiments show that serum from vaccinated animals, when injected on days 4 or 5 after challenge, protected animals from lethal disease.
Number:7,217,812
Date:2007-05-15
Type: Issued
Category: Vaccine
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Lab:WRAIR
Inventor(s):HOOPER, J.; SCHMALJOHN, C.; CUSTER, M.
For Licensing Opportunities, please contact the ORTA at USAMRMCORTA@amedd.army.mil