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Users Highlights

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GM/CA @ APS Sponsors:
National Institute of General Medical Sciences (NIGMS) and National Cancer Institute (NCI) of the National Institutes of Health (NIH)

Experiments at the GM/CA beamlines have resulted in many world-class results in the field of molecular biology. Here are some excerpts from the users works of GM/CA @ APS:

2015 2014 2013 2012 2011 2010 2009 2008 2007 2006
GM/CA users highlights
2015
	The Chemokine receptor, CX3CL1. Chris Garcia group (Stanford University).
	Structures of lysosomal phospholipase A2, important in cholesterol metabolism. John Tesmer group (University of Michigan) and collaborators.
	The Chemokine receptor, CXCR4. Tracy Handel group (University of California - San Diego) and Ray Stevens group (The Scripps Research Institute).
	Structure of human DNA pol theta - a role in breast cancer. Sylvie Doublie group (University of Vermont).
	Structure of TSPO. Shelagh Ferguson-Miller group (Michigan State University).
2014
	Structures of Adenovirus cement proteins. Vijay Reddy and Glen Nemerow (The Scripps Research Institute).
	Structure of the human subtype 2 orexin receptor (OX₂R). Daniel Rosenbaum group (University of Texas Southwest Medical Center).
	Structure of the diabetes-related human receptor protein GPR40. Gyorgy Snell group (Takeda pharmaceutical company).
	The smoothened receptor. Ray Stevens group (The Scripps Research Institute) and collaborators.
	Structure of a Class C GPCR metabotropic glutamate receptor. Ray Stevens group (The Scripps Research Institute) and collaborators.
	Icosahedral bacteriophage Phi X174 forms a tail for DNA transport during infection. Michael Rossmann group (Purdue University) and collaborators.
2013
	Structure of a conserved regulator of cyclin-dependent kinase (CDK). Seth Rubin group (University of California - Santa Cruz).
	Structure of a maltose transporter in complex with regulatory proteins. Jue Chen group (Purdue University).
	Structural Rearrangement of Ebola Virus VP40 Yields Multiple Functions in the Virus Life Cycle. Erica Ollmann Saphire group (The Scripps Research Institute) and collaborators.
	Adrenaline-activated structure of the beta 2 adrenoceptor stabilized with an engineered nanobody. Brian Kobilka group (Stanford University) and collaborators.
	Activation and allosteric modulation of a muscarinic acetylcholine receptor. Brian Kobilka group (Stanford University) and collaborators.
	The structure of beta-arrestin. Brian Kobilka group (Stanford University) and collaborators.
	First crystal structure of a true glucose transporter. Jun-Yong Choe group (Rosalind Franklin University).
	Translocation intermediate in cellulose synthesis and transport. Jochen Zimmer group (University of Virginia).
	New Crystal Structure Helps Explain 50 Years of Research on a Novel Membrane Enzyme in E. coli. Martin Caffrey group (Trinity College Dublin).
	First structure of a eukaryotic phosphate transporter revealed. Robert Stroud group (University of California - San Francisco) and collaborators.
	Epigenetics. Yawen Bai group (National Cancer Institute, NIH) and collaborators.
	HIV immunogen design using structural biology and nanotechnology. Ian Wilson group (The Scripps Research Institute) and collaborators.
	Structure of a monotropic membrane enzyme. Michael Malkowski group (Hauptman-Woodward Medical Research Institute and SUNY - Buffalo) and collaborators.
	Serotonin receptors. Ray Stevens group (The Scripps Research Institute) and collaborators.
	Structure of a GPCR bound to an anti-tumor agent. Ray Stevens group (The Scripps Research Institute) and collaborators.
	Mammalian GIRK2-βγ G-protein complex. Rod MacKinnon group (The Rockefeller University).
2012
	Muscarinic acetylcholine receptors. Brian Kobilka group (Stanford University) and collaborators.
	Structures of mu-opioid and delta-opioid receptors. Brian Kobilka group (Stanford University) and collaborators.
	Structure of a protease-activated GPCR. Brian Kobilka group (Stanford University) and collaborators.
	Ubiquitination complex plays a role in DNA repair. Cynthia Wolberger group (The Johns Hopkins University).
	Yeast mitochondrial proton turbine. David Mueller group (Rosalind Franklin University) and collaborators.
	An immune response to bacterial invasion. Ian Wilson group (The Scripps Research Institute) and collaborators.
	Tackling drug resistance in chemotherapy. Jue Chen group (Purdue University).
	Structure of neurotensin receptor NTS1. Reinhard Grisshammer group (The National Institutes of Health) and collaborators.
	Structure of the human two-pore domain potassium ion channel TRAAK. Rod MacKinnon group (The Rockefeller University).
	Structures of kappa-opioid and nociceptin/orphanin FQ receptors. Ray Stevens group (The Scripps Research Institute) and collaborators.
	Structure of a GPCR target for multiple sclerosis treatment. Ray Stevens group (The Scripps Research Institute) and collaborators.
	High-resolution structure of an adenosine receptor. Ray Stevens group (The Scripps Research Institute) and collaborators.
	DNA mismatch repair. Wei Yang group (The National Institutes of Health).
	Structure of a sodium-ion/calcium-ion exchanger. Youxing Jiang group (University of Texas - Southwestern).
2011
	First structure of a complex between a G protein coupled receptor (GPCR) and its G protein revealed. Brian Kobilka group (Stanford University) and collaborators.
	Nanobody-stabilized GPCR. Brian Kobilka and Bill Weis groups (Stanford University) and collaborators.
	Structure of Mediator head module revealed. Yuichiro Takagi group (Indiana University School of Medicine) and collaborators.
	Visualizing an Intermediate State of the Maltose Transporter. Jue Chen group (Purdue University).
	Structural Basis for Methyl Transfer by a Radical SAM Enzyme. Amy Rosenzweig group (Northwestern University) and collaborators.
	Designing antibodies to Influenza. Ian Wilson group (The Scripps Research Institute) and collaborators.
	Complex formation in the M1-fibrinogen network. Partho Ghosh group (University of California, San Diego) and collaborators.
	Allosteric activation of Protein Kinase C. James Hurley group (National Institutes of Health) and collaborators.
	A structure of the Sindis virus capsid. Michael Rossmann group (Purdue University) and colleagues.
	First structure of a protein-activated GPCR. Ray Stevens group (The Scripps Research Institute) and collaborators.
	Jasmonate Perception. Ning Zheng group (University of Washington) and collaborators.
	Oxidative Demethylation in crystallo. Chuan He group (University of Chicago) and collaborators.
	Epigenetics. Ben Black group (University of Pennsylvania).
	Synthesis of microbial natural products. George Phillips group (University of Wisconsin - Madison) and collaborators.
	Towards an effective HIV vaccine. Ian Wilson group (The Scripps Research Institute) and collaborators.
	Advances in crystallization in mesophases. Martin Caffrey group (Trinity College Dublin).
2010
	Beta adrenergic receptors. Brian Kobilka and Bill Weis groups (Stanford University) and collaborators.
	Enzymology in the crystal. Carrie Wilmot group (University of Minnesota).
	A 1.8-MDa SAGA complex. Cynthia Wolberger group (Johns Hopkins University) and collaborators.
	"Swine flu" virus similar to 1918 "Spanish flu" virus. Ian Wilson group (The Scripps Research Institute) and collaborators.
	Broadly reactive antibody neutralizes HIV-1Beta adrenergic receptors. Ian Wilson group (The Scripps Research Institute) and collaborators.
	Visual chromophore recycling. Krzysztof Palczewski group (Case Western Reserve University) and collaborators.
	Structure of the human adenovirus capsid. Vijay Reddy group (The Scripps Research Institute) and collaborators.
2009
	A full-length potassium channel. Anthony Kossiakoff group (University of Chicago) and collaborators.
	Identification of a nuclear receptor as a therapeutic target in parasitic nematodes. David Mangelsdorf group (University of Texas Southwestern Medical Center) and collaborators.
	Myxopyronin inactivation of RNA polymerase. Dmitry Vassylyev group (University of Alabama) and collaborators.
	A broadly neutralizing antibody to influenza virus. Ian Wilson group (The Scripps Research Institute) and collaborators.
	ErbB2, a therapeutic target in cancer. Mark Lemmon group (University of Pennsylvania).
	Genome ejection from mature bacteriophageT4 capsids during infection. Michael Rossmann group (Purdue University) and collaborators.
	Repair of oxidative damage to DNA. Sylvie Doublié group (University of Vermont).
	Cytochrome c Oxidase. Shelagh Ferguson-Miller group (Michigan State University).
2008
	A fence-like coat for the nuclear pore. Günter Blobel group (The Rockefeller University).
	Terminating translation. Harry Noller group (University of California - Santa Cruz).
	Stop codon recognition in translation termination. Harry Noller group (University of California - Santa Cruz).
	A non-human glycan mediates human susceptibility to a bacterial toxin. Jamie Rossjohn group (Monash University) and collaborators.
	DNA packaging into bacteriophageT4 procapsids. Michael Rossmann group (Purdue University) and collaborators.
	Structure of a bacterial-cell-wall-degrading enzyme in the bacteriophage phi29 tail. Michael Rossmann group (Purdue University) and collaborators.
	Parkinson's Disease and GPCRs. Ray Stevens group (The Scripps Research Institute).
	Recognition of hemi-methylated DNA. Sirano Dhe-Paganon (University of Toronto) and collaborators.
	Synthetic antibodies for crystallization of structured RNA. Anthony Kossiakoff group (University of Chicago) and collaborators.
	A structure of a tyrosyl-tRNA synthetase splicing factor bound to a group I intron RNA. Barbara Golden group (Purdue University).
	A designed ion channel. Chris Miller group (Brandeis University)
	Membrane protein: Polysulfide reductase. Mika Jormakka group (University of New South Wales) and collaborators.
	Telomere binding proteins. Ming Lei group (University of Michigan).
	EGFR ligand sequestration by Argos. Mark Lemmon group (University of Pennsylvania).
	Structure of a kinase-bound inhibitor of melanoma growth and invasiveness. Ronen Marmorstein group (Wistar Institute).
	Catechol O-methyltransferase. Ron Stenkamp and Bill Parson groups (University of Washington).
	Adenovirus fibers. Vijay Reddy group (The Scripps Research Institute) and collaborators.
2007
	The human β₂-adrenergic G-protein-coupled receptor. Brian Kobilka, Bill Weis groups (Stanford University), and Ray Stevens, Peter Kuhn groups (The Scripps Research Institute) and collaborators.
	Crystal structure of an enzyme involved in Gaucher disease. Greg Petsko and Dagmar Ringe groups (Brandeis University).
	Crystal structure related to rheumatic autoimmune diseases. James Sacchettini group (Texas A&M; University).
	Structure of enzyme domain involved in synthesis of natural products. Janet Smith group (University of Michigan) and collaborators.
	Structures from the SARS-CoV proteomics project. Peter Kuhn group (The Scripps Research Institute) and collaborators.
2006
	Guests, and hosts, and microfluidics. Rustem Ismagilov group (University of Chicago).
ANL Press Releases highlighting studies at GM/CA
	Mar, 2015: Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics.
	Sept, 2014: X-rays unlock a protein's SWEET side.
	July, 2014: Unprecedented detail of intact neuronal receptor offers blueprint for drug developers.
	Feb, 2014: Decoding dengue and West Nile: Researchers take steps toward control of growing public health problems.
	May, 2013: New approach to vaccine design targets HIV and other fast-mutating viruses.
	Oct, 2012: Advanced Photon Source lights the way to 2012 Chemistry Nobel.
	April, 2012: How heroin works: Imaging opioid receptors in the brain.
	March, 2009: Research could lead to more comprehensive flu vaccines.
APS Science Highlights based on studies at GM/CA
	May, 2015: The Mysterious "Mimivirus" is Not So Mysterious Anymore.
	Feb, 2015: A Key Cellular Gatekeeper.
	Jan, 2015: Pictured Together for the First Time: a Chemokine and its Receptor.
	Aug, 2014: Blueprints of a Bacterial Infection.
	Nov, 2013: The Most Detailed Picture Yet of a Key AIDS Protein.
	Sept, 2013: How HIV Infects Cells.
	July, 2013: A Key Target for Diabetes Drugs.
	May, 2013: How Serotonin Receptors Can Shape Drug Effects, from LSD to Migraine Medication.
	Nov, 2012: Architecture and Viral Disease.
	Oct, 2012: Outsmarting Flu Viruses.
	June, 2012: Computer-Designed Proteins to Disarm a Variety of Flu Viruses.
	Oct, 2011: How a Powerful Antibody Neutralizes HIV.
	Aug, 2011: Sending a Message: How Receptors Talk to G Proteins.
	March, 2011: New Clues for Asthma Treatment.
	Dec, 2010: How a Virus Prepares to Infect Cells.
	Sept, 2010: At the Crossroads of Chromosomes.
	Sept, 2010: Unveiling the Structure of Adenovirus.
	March, 2010: The Structure of the "Swine Flu" Virus.
	Sept, 2009: Boron-Based Compounds Trick a Biomedical Protein.
	March, 2009: The Crystal Structure of a Meta-stable Intermediate Particle in Virus Assembly .
	May, 2008: A Fruit-Fly Protein that Captures Tumor Growth Factors.
	Feb, 2008: Striking Nano Gold.
	Dec, 2007: Unveiling the Molecular Structure of the Target of Many Drugs.

See also: List of GM/CA @ APS users publications.

GM/CA @ APS is an Office of Science User Facility operated for the U.S. Department of Energy Office of Science by Argonne National Laboratory

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