Seminars for the The Mass Spectrometry Interest Group of the NCI at Frederick will generally be scheduled for the 3rd Tuesday of each month for 2013. A seminar is usually a 40-45 minute presentation on a topic of general interest followed by open discussion.

Separate from the seminars, there will also be smaller meetings which will consist of a 20-30 minute presentation on a topic of specific interest followed by open discussion. Meetings will not have a regular schedule.

Seminar

Speaker: Sanford Markey, Laboratory of Neurotoxicology, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD

Topic: "Of Rats and Men: Reflections on Past and Current Research at NIH"

Place: Building 549, Auditorium, Frederick National Laboratory for Cancer Research, Frederick, MD - Need Directions?

Time: Tuesday, March 5, 2013, at 2:00 PM

Abstract: From the early days of GC-MS when success required mastery of the arts and sciences of glass blowing and derivatization chemistry to the present era of proteomics with high performance LC/MS/MS instrumentation, the capacity of mass spectrometry to provide definitive, unbiased answers has brought intriguing biomedical problems into our labs. I will describe some past research, and describe how a new technique, invented by a multi-disciplinary trans-NIH team, is being implemented for high-throughput micro sample procurement. Expression Microdissection (xMD) retrieves subcellular components or discrete cells directly from stained tissue sections in an unsupervised manner, and permits subsequent proteome analyses of the targeted, enriched material.

Poster

Authors: Ramessar K, Krumpe L, Xiong C-Y, Wilson J, McMahon JB and O'Keefe BR, Molecular Targets Laboratory, Center for Cancer Research, NCI-Frederick

Title: Isolation, Characterization and Recombinant Production of a Novel Anti-HIV Protein, CNIDARIN1

Place: Building 549, Lobby, Frederick National Laboratory for Cancer Research, Frederick, MD

Time: Displayed from 10:00 AM until 3:30 PM: Questions and discussion after seminar.

First Presented: At the NCI’s Spring Research festival, Frederick MD, 27-28 April 2011