Ebola Drug Test Database

(-) -Levobunolol hydrochloride

Aliases: Betagen

Mechanism of Action: noncardioselective beta-adrenoceptor blocking agent for ophthalmic use

Clinical Experience: FDA-approved

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: (-) -Levobunolo - NCGC00016801-05.pdf

(-)-Scopolamine methyl bromide

Aliases: Pamine

Mechanism of Action: Anticholinergic

Clinical Experience: FDA-approved

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: (-)-Scopolamine - NCGC00022697-03.pdf

(S)-Timolol maleate

Aliases: Timoptic

Mechanism of Action: beta-adrenergic receptor antagonist

Clinical Experience: FDA-approved

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: (S)-Timolol mal - NCGC00016798-11.pdf

1,8-Cineol

Aliases: Eucalyptol, 1,8-cineole, cajeputol, 1,8-epoxy-p-menthane, 1,8-oxido-p-menthane, eucalyptol, eucalyptole, 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane, cineol, cineole.

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1,8-Cineol - NCGC00091666-04.pdf

10-Undecenoic acid

Aliases: Undecylenic acid, Gordochrom

Mechanism of Action: anti-fungal (topical)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 10-Undecenoic a - NCGC00159425-04.pdf

1-Bromoheptadecafluorooctane

Aliases:

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1-Bromoheptadec - NCGC00166217-02.pdf

1-Ethyl-2-pyrrolidone

Aliases:

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1-Ethyl-2-pyrro - NCGC00160611-03.pdf

1-Hexadecanol

Aliases: Cetyl alcohol, palmityl alcohol

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1-Hexadecanol - NCGC00159368-05.pdf

1-Octadecanol

Aliases: Stearyl alcohol, octadecyl alcohol

Mechanism of Action: emulsifier (cosmetics and personal care products)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1-Octadecanol - NCGC00159369-04.pdf

1-Octanoyl-rac-glycerol

Aliases: Monocaprylin

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1-Octanoyl-rac- - NCGC00166144-03.pdf

1-Stearoyl-rac-glycerol

Aliases:

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 1-Stearoyl-rac- - NCGC00164529-04.pdf

2,3-DIMERCAPTOSUCCINIC ACID

Aliases: CHEMET, succimer

Mechanism of Action: heavy metal chelating agent

Clinical Experience: FDA-approved

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2,3-DIMERCAPTOS - NCGC00264003-02.pdf

2-Ethyl-1,3-hexanediol

Aliases: Ethylhexylene glycol

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Ethyl-1,3-hex - NCGC00091575-03.pdf

2-Ethylhexyl 4-dimethylaminobenzoate

Aliases: Padimate O

Mechanism of Action: Absorbs UV rays (sunscreen)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Ethylhexyl 4- - NCGC00090764-04.pdf

2-Ethylhexyl salicylate

Aliases: Octyl salicylate

Mechanism of Action: Absorbs UV rays (sunscreen)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Ethylhexyl sa - NCGC00159324-04.pdf

2-Ethylhexyl trans-4-methoxycinnamate

Aliases:

Mechanism of Action: Absorbs UV rays (sunscreen)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Ethylhexyl tr - NCGC00160623-04.pdf

2-Hydroxy-4-methoxybenzophenone

Aliases: Oxybenzone, benzophenone-3

Mechanism of Action: Absorbs UV rays (sunscreen)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Hydroxy-4-met - NCGC00016394-10.pdf

2-Iodohippuric acid

Aliases:

Mechanism of Action: contrast agent

Clinical Experience: FDA-approved

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Iodohippuric - NCGC00160456-03.pdf

2-Octyl-1-dodecanol

Aliases:

Mechanism of Action: emulsifier (cosmetics and personal care products)

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 2-Octyl-1-dodec - NCGC00166213-02.pdf

4-(1,1,3,3-Tetramethylbutyl)phenol

Aliases:

Mechanism of Action:

Clinical Experience:

Tested In:

Mice (Ebola)	GP (Ebola)	NHP (Ebola)	Other (Ebola)	In Vitro (Ebola)
No	No	No	No	Yes

Comments:

Screening result for entry of beta-lactamase containing Ebola VLPs in to HeLA cells loaded with beta-lactamase substrate CCF2-AM.

Full report: 4-(1,1,3,3-Tetr - NCGC00164127-03.pdf