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    DEPArray Technology for Rare Cell IsolationThis automated platform enables users to identify and recover specific individual cells of interest from complex, heterogeneous samples for downstream genomic analysis. ...Read More

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    The NIH IRP Collaborative Research Exchange (CREx)The Collaborative Research Exchange (CREx) is an online CCR marketplace where investigators can search, browse, and request information for research services, technologies, or products offered by NCI Cores and Collaborat...Read More

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    C1 Autoprep System now available to CCR investigatorsCCR investigators now have access to Fluidigm's C1 Single Cell Autoprep System through the CCR Genomics Core in Building 37 ...Read More

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    NCI Capabilities in Next Generation DNA SequencingThe CCR has access to capabilities in the area of Next Generation DNA Sequencing through laboratories including the CCR Sequencing Facility, the Laboratory of Molecular Technology, and the CCR Genomics Core. ...Read More

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    The CCR Bioinformatics Training and Education Program (BTEP)The CCR Bioinformatics Training and Education Program has the objective of assisting and enabling CCR researchers with the management and analysis of the massive amounts of data emerging out of experiments relating to hi...Read More

New Technologies, Scientific Resources

The Office of Science and Technology Resources (OSTR) identifies, evaluates and makes available new technologies and scientific resources to NCI's Center for Cancer Research (CCR) investigators through partnerships, collaborations, contracts and other technology transfer agreements with outside organizations, including the private sector.

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OSTR-Supported Technologies in CCR Publications

An Apela RNA-Containing Negative Feedback Loop Regulates p53-Mediated Apoptosis in Embryonic Stem Cells: J. Huang Lab
Highlights • Apela is enriched in mouse ESCs and repressed by p53 • Apela positively regulates DNA damage-induced apoptosis in mouse ESCs • The protein-coding capacity of Apela is not required for DNA damage-induced apoptosis • Apela binds to hnRNPL, an inhibitory binding partner of p53 in mouse ESCs
Capillary nano-immunoassays: advancing quantitative proteomics analysis, biomarker assessment, and molecular diagnostics: Jessie Chen, Ph.D. (Collaborative Proteomics Technology Resource)
In this manuscript, we review the performance and applications of a novel capillary nano-immunoassay (CNIA) system (The Simple Western System™, marketed by ProteinSimple, CA, USA), a fully automated capillary electrophoresis system for characterization of proteins and their post-translational modifications. This new system overcomes many of the limitations of conventional proteomic approaches: it offers straightforward target specific detection, easy operation, high quality data quantitation and excellent assay reproducibility using nanogram levels of sample. This technology has been successfully applied in the dissection of signaling pathways, assessment of proteomic biomarkers, and evaluation of targeted therapies.
MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis: Yuspa Lab
Cataisson et al. found that cutaneous SCC was associated with high amounts of hepatocyte growth factor (HGF), which activates the receptor MET. In transgenic mouse models, HGF and oncogenic RAS each activated a common downstream transcriptional program in skin cells, resulting in stimulation of the epidermal growth factor receptor (EGFR) pathway through the production and secretion of its ligands. Furthermore, established squamous tumors in mice regressed when this activation of or signaling by this EGFR pathway was blocked. In some human SCCs, high HGF and activated MET correlated with an EGFR-activating gene signature like the one identified in the mice, indicating that this pathway may offer therapeutic targets for patients.

Calendar of Events

Tomorrow

  1. CCR Grand Rounds
    • Where: Lipsett Amphitheater, Bldg 10
    • Start time: 12:00pm
    • End time: 1:00pm
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Friday, December 2nd

  1. CCR Grand Rounds
    • Where: Lipsett Amphitheater, Bldg 10
    • Start time: 12:00pm
    • End time: 1:00pm
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Friday, December 9th

  1. CCR Grand Rounds
    • Where: Lipsett Amphitheater, Bldg 10
    • Start time: 12:00pm
    • End time: 1:00pm
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