Publications
Search Medline for all papers by Tom Dever (Dever, TE).
Browse older publications from the Dever lab.
List of recent publications, for the years 2004 through 2011:
- Shin, B.S., Kim, J.R., Walker, S.E., Dong, J., Lorsch, J.R., and Dever, T.E.: Initiation factor eIF2γ promotes eIF2–GTP–Met-tRNAiMet ternary complex binding to the 40S ribosome. Nat Struct Mol Biol. 18:1227-34, 2011.
- Rothenburg, S., Chinchar, V.G., and Dever, T.E.: Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. BMC Microbiol. 11:56, 2011.
- Dey, M., Velyvis, A., Li, J.J., Chiu, E., Chiovitti, D., Kay, L.E., Sicheri, F., and Dever, T.E.: Requirement for kinase-induced conformational change in eukaryotic initiation factor 2α (eIF2α) restricts phosphorylation of Ser51. Proc. Natl. Acad. Sci. USA. 108:4316-21, 2011.
- Shin, B.S., Acker, M.G., Kim, J.R., Maher, K.N., Arefin, S.M., Lorsch, J.R., and Dever, T.E.: Structural integrity of α-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability. RNA 17:687-96, 2011.
- Lorsch, J.R. and Dever, T.E.: Molecular view of 43S complex formation and start site selection in eukaryotic translation initiation. J. Biol. Chem. 285:21203-21207, 2010.
- Dev, K., Santangelo, T.J., Rothenburg, S., Neculai, D., Dey, M., Sicheri, F., Dever, T.E., Reeve, J.N., and Hinnebusch, A.G.: Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2a and eIF2Bα: Implications for aIF2B function and eIF2B regulation. J. Mol. Biol. 392:701-722, 2009.
- Saini, P., Eyler, D.E., Green, R., and Dever, T.E.: Hypusine-containing protein eIF5A promotes translation elongation. Nature 459:118-121, 2009.
- Garriz, A., Qiu, H., Dey, M., Seo, E.J., Dever, T.E., and Hinnebusch, A.G.: A network of hydrophobic residues impeding helix aC rotation maintains latency of eIF2α kinase GCN2. Mol. Cell. Biol. 29:1592-1607, 2009.
- Shin, B.S., Kim, J.-R., Acker, M.G., Maher, K.N., Lorsch, J.R., and Dever, T.E.: rRNA suppressor of an eIF5B/IF2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit. Mol. Cell. Biol. 29:808-821, 2009.
- Acker, M.G., Shin, B.-S., Nanda, J.S., Saini, A.K., Dever, T.E., and Lorsch, J.R.: Kinetic analysis of late steps of eukaryotic translation initiation. J. Mol. Biol. 385:491-506, 2009.
- Rothenburg, S., Seo, E.J., Gibbs, J.S., Dever, T.E., and Dittmar, K.: Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors. Nature Struct. Mol. Biol. 16:63-70, 2009.
- Seo, E.J., Liu, F., Kawagishi-Kobayashi, M., Ung, T.L., Cao, C., Dar, A.C., Sicheri, F., and Dever, T.E.: Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proc. Natl. Acad. Sci. USA 105:16894-16899, 2008.
- Alone, P.V., Cao, C., and Dever, T.E.: Translation initiation factor eIF2γ mutant alters start codon selection independent of Met-tRNA binding. Mol. Cell. Biol. 28:6877-6888, 2008.
- Costa-Mattioli, M., Bidinosti, M., and Dever, T.E.: Getting the message in protein synthesis. Keystone Symposium on Translational Regulatory Mechanisms. EMBO Rep. 9:954-959, 2008.
- Rothenburg, S., Deigendesch, N., Dey, M., Dever, T.E., and Tazi, L.: Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying number of double-stranded RNA binding domains and lineage specific duplications. BMC Biology 6:12, 2008.
- Lee, K.P.K., Dey, M., Neculai, D., Cao, C., Dever, T.E., and Sicheri, F.: Crystal structure of the dual catalytic region of Ire1 reveals the basis for catalysis and regulation in non-conventional RNA splicing. Cell 132:89-100, 2008.
- Moraes, M.C., Jesus, T.C., Hashimoto, N.N., Dey, M., Schwartz, K.J., Alves, V.S., Avila, C.C., Bangs, J.D., Dever, T.E., Schenkman, S., and Castilho, B.A.: Novel membrane-bound eIF2α kinase in the flagellar pocket of Trypanosoma brucei. Eukaryot. Cell 6:1979-1991, 2007.
- Shin, B.S. and Dever, T.E.: Molecular genetic structure-function analysis of translation initiation factor eIF5B. Methods Enzymol. 429:185-201, 2007.
- Fringer, J.M., Acker, M.G., Fekete, C.A., Lorsch, J.R., and Dever, T.E.: Coupled release of factors eIF5B and eIF1A from 80S ribosomes following subunit joining. Mol. Cell. Biol. 27:2384-2397, 2007.
- Dey, M., Cao, C., Sicheri, F., and Dever, T.E.: Conserved intermolecular salt-bridge required for activation of protein kinases PKR, GCN2 and PERK. J. Biol. Chem. 282:6653-6660, 2007.
- Shin, B.S., Acker, M.G., Maag, D., Kim, J.-R., Lorsch, J.R., and Dever, T.E.: Intragenic suppressor mutations restore GTPase and translation functions of eIF5B switch II mutant. Mol. Cell. Biol. 27:1677-1685, 2007.
- Dever, T.E., Dar, A.C., and Sicheri, F.: The eIF2α Kinases. In: Mathews, M.B., Sonenberg, N., and Hershey, J.W.B., eds. Translational Control in Biology and Medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 319-344, 2007.
- Hinnebusch, A.G., Dever, T.E., and Asano, K.: Mechanism of Translation Initiation in the Yeast Saccharomyces cerevisiae. In: Mathews, M.B., Sonenberg, N., and Hershey, J.W.B., eds. Translational Control in Biology and Medicine. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 225-268, 2007.
- Alone, P.V. and Dever, T.E.: Direct binding of translation initiation factor eIF2γ-G domain to its GTPase-activating and GDP-GTP exchange factors eIF5 and eIF2Be. J. Biol. Chem. 281:12636-12644, 2006.
- Acker, M.G., Shin, B.-S., Dever, T.E., and Lorsch, J.R.: Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining. J. Biol. Chem. 281:8469-8475, 2006.
- Dey, M., Cao, C., Dar, A.C., Tamura, T., Ozato, K., Sicheri, F., and Dever, T.E.: Mechanistic link between PKR dimerization, autophosphorylation, and eIF2α substrate recognition. Cell 122:901-913, 2005.
- Dar, A.C., Dever, T.E., and Sicheri, F.: Higher-order substrate recognition of eIF2α by the RNA-dependent protein kinase PKR. Cell 122:887-900, 2005.
- Dever, T.E. and Hinnebusch, A.G.: GCN2 Whets the Appetite for Amino Acids. Mol. Cell 18:141-142, 2005.
- Dey, M., Trieselmann, B., Locke, E.G., Lu, J., Cao, C., Dar, A.C., Krishnamoorthy, T., Dong, J., Sicheri, F., and Dever, T.E.: PKR and GCN2 Kinases and Guanine Nucleotide Exchange Factor Eukaryotic Translation Initiation Factor 2B (eIF2B) Recognize Overlapping Surfaces on Translation Factor eIF2α. Mol. Cell. Biol. 25:3063-3075, 2005.
- Hinnebusch, A.G., Dever, T.E., and Sonenberg, N.: Mechanism and Regulation of Protein Synthesis Initiation in Eukaryotes. In Protein Synthesis and Ribosome Structure (ed. K.H. Nierhaus and D.N. Wilson) Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, pp. 241-322, 2005.
- Klann, E. and Dever, T.E.: Biochemical mechanisms for translational regulation in synaptic plasticity. Nat. Rev. Neurosci. 5:931-942, 2004.
- Kazemi, S., Papadopoulou, S., Li, S., Su, Q., Wang, S., Yoshimura, A., Matlashewski, G., Dever, T.E., and Koromilas, A.E.: Control of eukaryotic translation initiation factor 2α (eIF2α) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2α-dependent gene expression and cell death. Mol. Cell. Biol. 24:3415-3429, 2004.
- Roll-Mecak, A., Alone, P., Cao, C., Dever, T.E., and Burley, S.K.: X-ray structure of translation initiation factor eIF2γ: implications for tRNA and eIF2α binding. J. Biol. Chem. 279:10634-10642, 2004.