Agenda

Overall Conference Objectives

To evaluate available evidence on the efficacy and safety of vitamin D, considering the Agency for Healthcare Research and Quality (AHRQ) evidence-based review entitled Effectiveness and Safety of Vitamin D, other recent and current research, particularly new research and related research tools made available since the original 2003 Office of Dietary Supplements (ODS) Conference on Vitamin D and Health in the 21st Century: Bone and Beyond. In particular, this evaluation will focus on vitamin D metabolism and status, 25(OH)D levels and functional outcomes across the life cycle, the impact of vitamin D dietary intakes and de novo production on 25(OH)D levels, and the toxicity and adverse outcomes of vitamin D.
Identify gaps in knowledge on the efficacy and safety of vitamin D in general and across the life cycle.
Inform NIH and other Federal Agencies on research priorities in the area of vitamin D and health.
Disseminate the conference proceedings and executive summary to inform the broader nutrition community.

Wednesday, September 5, 2007
8:00 a.m.	Registration
8:30 a.m.–8:40 a.m.	Introduction Mary Frances Picciano Office of Dietary Supplements, NIH
Session 1:	Vitamin D Metabolism and Status Moderator: Joan McGowan National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH
8:40 a.m.–9:15 a.m.	Vitamin D Metabolism and Functions Anthony Norman University of California, Riverside
9:15 a.m.–9:25 a.m.	Questions and Answers
9:25 a.m.–9:45 a.m.	Assessment of Nutritional Status: Biomarkers and Nutritional Assessment Lars Ovesen Department of Gastroenterology, Slagelse Hospital
9:45 a.m.–9:55 a.m.	Questions and Answers
9:55 a.m.–10:15 a.m.	Vitamin D Across the Life Cycle Ann Prentice Medical Research Council Human Nutrition Center
10:15 a.m.–10:25 a.m.	Questions and Answers
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10:25 a.m.–10:50 a.m.	Break
10:50 a.m.–11:10 a.m.	Measuring 25(OH)D: Challenges and Needs Bruce Hollis Medical University of South Carolina
11:10 a.m.–11:20 a.m.	Questions and Answers
11:20 a.m.–11:30 a.m.	Measuring 25(OH)D: Standard Reference Material Karen Phinney National Institute of Standards and Technology
11:30 a.m.–11:35 a.m.	Questions and Answers
11:35 a.m.–11:55 a.m.	Vitamin D Status Anne Looker National Center for Health Statistics
11:55 a.m.–12:05 p.m.	Questions and Answers
12:05 p.m.–12:50 p.m.	Session 1 Panel and Audience Discussion Norman, Ovesen, Prentice, Hollis, Phinney, and Looker Questions posed to panel and audience: What research gaps need to be addressed to validate biomarkers and assessment standards of vitamin D status and their measurement in individuals and populations? Given current understanding of biomarkers and their relationship to functional outcomes for vitamin D, what interpretation can be given to population or study results that use serum 25(OH)D levels as the primary outcome or determinant of adequate vitamin D status?
12:50 p.m.–1:50 p.m.	Lunch on own
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1:50 p.m.–2:00 p.m.	Vitamin D and Cancer—Current Dilemmas and Future Needs: A Summary of the NCI Conference Cindy Davis National Cancer Institute, NIH
2:00 p.m.–2:05 p.m.	Questions and Answers
Session 2, Part 1:	25(OH)D and Functional Outcomes Across the Life Cycle Moderator: Munro Peacock Indiana University School of Medicine
2:05 p.m.–2:20 p.m.	Evidence-Based Review: Overview Ann Cranney University of Ottawa
2:20 p.m.–2:30 p.m.	Questions and Answers
2:30 p.m.–2:45 p.m.	Evidence-Based Review: Results—Question 1 Hope Weiler McGill University
2:45 p.m.–2:55 p.m.	Questions and Answers
2:55 p.m.–3:15 p.m.	25(OH)D and Functional Outcomes in the Elderly Bess Dawson-Hughes Tufts University Human Nutrition Research Center on Aging
3:15 p.m.–3:25 p.m.	Questions and Answers
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3:25 p.m.–3:50 p.m.	Break
3:50p.m.–4:10 p.m.	25(OH)D and Functional Outcomes in Pregnancy and Lactation Christopher Kovacs Memorial University of Newfoundland, Health Sciences Center
4:10 p.m.–4:20 p.m.	Questions and Answers
4:20 p.m.–4:40 p.m.	25(OH)D and Functional Outcomes in the Fetus and Infant Frank Greer University of Wisconsin
4:40 p.m.–4:50 p.m.	Questions and Answers
4:50 p.m.–5:10 p.m.	25(OH)D and Functional Outcomes in Adolescents Christel Lamberg-Allardt University of Helsinki
5:10 p.m.–5:20 p.m.	Questions and Answers
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Thursday, September 6, 2007
Session 2, Part 2:	25(OH)D and Functional Outcomes Across the Life Cycle Moderator: Irwin Rosenberg Tufts University Human Nutrition Research Center on Aging
8:30 a.m.–8:50 a.m.	Interactions of 25(OH)D With Calcium and Functional Outcomes Robert Heaney Creighton University
8:50 a.m.–9:00 a.m.	Questions and Answers
9:00 a.m.–9:20 a.m.	African Americans, 25(OH)D, and Osteoporosis: A Paradox? John Aloia Winthrop University Hospital
9:20 a.m.–9:30 a.m.	Questions and Answers
9:30 a.m.–10:30 a.m.	Session 2 Panel and Audience Discussion Cranney, Weiler, Dawson-Hughes, Kovacs, Greer, Lamberg-Allardt, Heaney, and Aloia Questions posed to panel and audience: What research gaps need to be addressed to answer the questions as to what is insufficient 25(OH)D across the life cycle and among ethnic groups? How do age, race, physical, and physiological conditions (pregnancy, obesity, renal/liver disease) affect vitamin D, its assessment biomarkers, and sufficiency across the life cycle?
10:30 a.m.–10:55 a.m.	Break
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Session 3:	Impact of Dietary Intake (Including Fortified Foods and Supplements) and Sun Exposure on 25(OH)D Moderator: Cindy Davis National Cancer Institute, NIH
10:55 a.m.–11:25 a.m.	Evidence-Based Review Results—Questions 2–4 Ann Cranney University of Ottawa
11:25 a.m.–11:35 a.m.	Questions and Answers
11:35 a.m.–11:45 a.m.	Assessing Vitamin D Contents in Food and Supplements: Challenges and Needs Joanne Holden U.S. Department of Agriculture, Beltsville Human Nutrition Research Center
11:45 a.m.–11:50 a.m.	Questions and Answers
11:50 a.m.–12:00 a.m.	Analyzing Vitamin D in Food and Supplements: Methodological Challenges James Harnly U.S. Department of Agriculture, Beltsville Human Nutrition Research Center
12:00 a.m.–12:05 a.m.	Questions and Answers
12:05 a.m.–12:25 p.m.	Intakes of Vitamin D, 25(OH)D, and Sufficiency: State of Our Knowledge and Its Uncertainties Elizabeth Yetley Office of Dietary Supplements, NIH
12:25 p.m.–12:35 p.m.	Questions and Answers
12:35 p.m.–1:35 p.m.	Lunch on own
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1:35 p.m.–1:55 p.m.	Sun Exposure, 25(OH)D, and Sufficiency Barbara Gilchrest Boston University School of Medicine
1:55 p.m.–2:05 p.m.	Questions and Answers
Session 4:	Toxicity and Adverse Outcomes Moderator: Christine Taylor Institute of Medicine, National Academy of Sciences
2:05 p.m.–2:15 p.m.	Evidence-Based Review Results—Question 5 Ann Cranney University of Ottawa
2:15 p.m.–2:25 p.m.	Questions and Answers
2:25 p.m.–2:45 p.m.	Assessing Adverse Outcomes of Essential Nutrients: Theoretical and Evidence-Based Approaches Daniel P. Hayes New York City Department of Health and Mental Hygiene
2:45 p.m.–2:55 p.m	Questions and Answers
2:55 p.m.–3:15 p.m.	Break
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3:15 p.m.–3:35 p.m.	Potential Adverse Outcomes of Vitamin D Reinhold Vieth University of Toronto
3:35 p.m.–3:45 p.m.	Questions and Answers
3:45 p.m.–4:05 p.m.	Pharmacokinetics of Vitamin D Toxicity Jim Riviere North Carolina State University
4:05 p.m.–4:15 p.m.	Questions and Answers
4:15 p.m.–5:00 p.m.	Session 3 and 4 Panel and Audience Discussion Cranney, Holden, Harnly, Yetley, Gilchrest, Hayes, Vieth, and Riviere Questions posed to panel and audience: What research gaps need to be addressed to understand the dietary intake, including that from fortified foods and supplements, the endogenous production of vitamin D, and the adverse outcomes of high intakes across life cycle, in ethnic groups and in various physiological or relevant disease states (such as kidney or liver disease)?
5:00 p.m.–5:15 p.m.	Conclusions Patsy Brannon Office of Dietary Supplements, NIH/Cornell University
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Agenda